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作者:高鹏飞
单位:河南科技大学第一附属医院呼吸与危重症医学科
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1. 诱导痰操作流程
2. 诱导痰的安全性
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图源:Virulence, 2020, 11(1):1394-1401.
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[2] Vlachos-Mayer H, Leigh R, Sharon R F, et al. Success and safety of sputum induction in the clinical setting[J]. Eur Respir J, 2000, 16(5):997-1000.
[3] Belda J, Leigh R, Parameswaran K, et al. Induced sputum cell counts in healthy adults[J]. Am J Respir Crit Care Med, 2000, 161(2 Pt 1):475-478.
[4] Green R H, Brightling C E, McKenna S, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial[J]. Lancet, 2002, 360(9347):1715-1721.
[5] McGrath K W, Icitovic N, Boushey H A, et al. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic[J]. Am J Respir Crit Care Med, 2012, 185(6):612-619.
[6] Taylor S L, Leong L E X, Choo J M, et al. Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology[J]. J Allergy Clin Immunol, 2018, 141(1):94-103.e15.
[7] Hastie A T, Martinez F J, Curtis J L, et al. Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort[J]. Lancet Respir Med, 2017, 5(12):956-967.
[8] Kesimer M, Ford A A, Ceppe A, et al. Airway Mucin Concentration as a Marker of Chronic Bronchitis[J]. N Engl J Med, 2017, 377(10):911-922.
[9] Ho T, Scallan C, Rezaee N, et al. Sputum quantitative cytometry in patients with interstitial lung disease and chronic cough[J]. Respir Med, 2020, 170:106067.
[10] Xie X, Wu J, Guo B, et al.Comprehensive characterization reveals sputum supernatant as a valuable alternative liquid biopsy for genome profiling in advanced non-small cell lung cancer[J]. Respir Res, 2022, 23(1):175.
[11]Andrade L S, Silva D R, Santos A P, et al. Molecular diagnosis of pulmonary tuberculosis using different respiratory specimens: The spotlight of induced sputum[J]. Pulmonology, 2022, 28(2):134-136.
[12] Lai T, Xiang F, Zeng J, et al. Reliability of induced sputum test is greater than that of throat swab test for detecting SARS-CoV-2 in patients with COVID-19: A multi-center cross-sectional study[J]. Virulence, 2020, 11(1):1394-1401.
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